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Chang Liu Vice Dean and Professor

Academic Title:

Director of Jiangsu Key Laboratory for Molecular and Medical Biotechnology
Member of the Chinese Society of Cell Biology and Fellow of the Medical Cell Biology Branch
Vice president of Jiangsu Society for Cell and Developmental Biology

Research Interests:

Molecular pathogenesis of metabolic syndromes, including type 2 diabetes, fatty liver, atherosclerosis and insulin resistance, especially the integration of circadian clock and energy metabolism regulation

 

Educational Background:
PhD, Pathophysiology, Institute of Molecular Medicine, Nanjing University (2005)
BS, Biochemistry and Molecular Biology, School of Life Sciences, Nanjing University, (1999)

Research Projects:
Program of the National Basic Research Program of China (973 Program; 2012CB947600, 2013CB911600)
Program of the National Natural Science Foundation of China (NSF; 31171137, 31422028, 31271261)
Ten Thousand Talents Program
Programs issued by Jiangsu Province of China [NSF (BK20140041) Six Talents Summit Project, and 333 Talents Project (BRA2015323)]
Program of the Key Project of Chinese Ministry of Education (211062)
the Research Fund for the Doctoral Program of Higher Education of China (20103207110007)
Program of the Fok Ying Tong Education Foundation (121022)
the Major Program of Educational Commission of Jiangsu Province (09KJA180004)
Program of the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine (Nanjing Medical University)
the Priority Academic Program Development of Jiangsu Higher Education Institutions

Journal Articles:
(1) Zhang W,Wang P,Chen S,Zhang Z,Liang T*,Liu C*,(2016) Rhythmic Expression of miR-27 Targets the Clock Gene Bmal1 through Post-transcriptional Rgulation in the Mouse Liver,The FASEB Journal, doi:10.1096/fj.201500120fj.201500120 (IF=5.043)
(2) Ge X, Chen S, Liu M, Liang T, Liu C*, (2015) Evodiamine Attenuates PDGF-BB-induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ,International Journal of Molecular Sciences,16(12):28180-28193 (IF=2.862)
(3) Wang D, Chen S & Liu C.* (2015) Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver. Chronobiology International, 32,1-12 (IF=4.35)
(4) Zhang J,Zhang J,Zhao C,Shen R,Guo X,Li C,Ling X *,Liu C *,(2014) Analysis of Transcription Factor Stk40 Expression and Function during Mouse Pre-implantation Embryonic Development, Molecular Medicine Reports, 9(2):535-540 (IF=1.544)
(5) Chen S, Qian J, Shi X, Gao T, Liang T & Liu C.* (2014) Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. Molecular Endocrinology, 28, 1987-1998. (IF=4.54)
(6) Chen S, Zhang W, Tang C, Tang X, Liu L & Liu C.* (2014) Vanin-1 is a key activator for hepatic gluconeogenesis. Diabetes, 63, 2073-2085. (IF=7.90)
(7) Chen S, Ding Y, Zhang Z, Wang H & Liu C.* (2014) Hyperlipidemia impairs the circadian clock and physiological homeostasis of vascular smooth muscle cells via the suppression of Smarcd1. Journal of Pathology, 233, 159-169 (cover story). (IF=7.59)
(8) Qian J, Chen S, Huang Y, Shi X & Liu C.* (2013) PGC-1α regulates hepatic hepcidin expression and iron homeostasis in response to inflammation. Molecular Endocrinology, 27, 683-692. (IF=4.54)
(9) Xu Y, Diao Y, Qi S, Pan X, Wang Q, Xin Y, Cao X, Ruan J, Zhao Z, Luo L*, Liu C*, Yin Z.* (2013) Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cellular Signalling, 25, 1176-1185. (IF=4.06)
(10) Wang Z, Zhang X, Chen S, Wang D, Wu J, Liang T & Liu C.* (2013) Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α. PLoS One, 8, e55471. (IF=4.41)
(11) Liang T, Guo L & Liu C.* (2012) Genome-wide analysis of mir-548 gene family reveals evolutionary and functional implications. Journal of Biomedicine and Biotechnology 2012, 679563. (IF=2.44)
(12) Yi N, Chen S, Ma A, Chen P, Yao B, Liang T & Liu C.* (2012) Tunicamycin inhibits PDGF-BB-induced proliferation and migration of vascular smooth muscle cells through induction of HO-1. Anatomical Record (Hoboken), 295, 1462-1472. (IF=1.47)
(13) Chen S, Ding Y, Tao W, Zhang W, Liang T & Liu C.* (2012) Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food and Chemical Toxicology, 50, 3025-3031. (IF=3.00)
(14) Tao W, Chen S, Shi G, Guo J, Xu Y & Liu C.* (2011) SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism. Hepatology, 54, 1410-1420. (IF=11.67)
(15) Liu C* & Lin JD.* (2011) PGC-1 coactivators in the control of energy metabolism. Acta Biochimica et Biophysica Sinica, 43, 248-257. (IF=1.55)
(16) Jiang F, Qian J, Chen S, Zhang W & Liu C.* (2011) Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. Pharmaceutical Biology, 49, 856-863. (IF=0.64)
(17) Yu X, Tao W, Jiang F, Li C, Lin J & Liu C.* (2010) Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. American Journal of Hypertension, 23, 895-903. (IF=3.13)
(18) Xu Y, Chen J, Yu X, Tao W, Jiang F, Yin Z & Liu C.* (2010) Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflammation Research, 59, 871-877. (IF=2.00)
(19) Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z & Liu C.* (2010) Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. Journal of Ethnopharmacology, 128, 438-445. (IF=2.47)

Honors and Awards:
Outstanding Youth Foundation of NCSF
Ten Thousand Talents Program
Distinguished Young Scholars of Jiangsu Province

Contact Information:
+86 25 85891870
changliu@njnu.edu.cn

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