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10 Achievements of the Year

Two-dimensional metal-organic framework nanosheets as an enzyme inhibitor: modulation of α-chymotrypsin Activity

xu_ming_2.jpgAuthor: Zhiyuan Gu, Ming Xu
Organization: School of Chemistry and Materials Science
The form of the achievement: paper
Introduction: The paper entitled “Two-dimensional Metal-organic Framework Nanosheets as an Enzyme Inhibitor: Modulation of α-chymotrypsin Activity” was published in the journal JACS (IF = 13.858), which is the leading journal in international chemical research, on May 24, 2017. Postgraduate Ming Xu is the lead author of this paper, and Prof. Zhiyuan Gu is corresponding author. This paper provides an inspiring means to enhance the control of cellular processes as well as improve our understanding of the surface chemistry between MOFs and enzymes, which received the international attention from experts in this field. This study not only opens up a new direction for the exploration of the MOF-bio interface in physiological and catalytic systems, but also provides a theoretical basis for the application of MOF in the biomedical field.

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